Cooling the Future with Liquid Ventilation
September 3, 2025
In a recent episode of Favorable Environments, the USD Discovery District’s podcast dedicated to advancing biotech and life sciences, Tung Nguyen sat down with Fabrice Paublant, CEO of Orixha. With over 30 years of experience in pharmaceuticals, consulting, and entrepreneurship, Mr. Paublant shared his journey and Orixha’s mission to transform post-cardiac arrest care through liquid ventilation technology.
A Diverse Career Fueling Innovation
Fabrice Paublant’s career is a testament to the power of diverse experiences in driving innovation. With a background in economics and business, including an MBA from MIT, Mr. Paublant has navigated roles across pharmaceuticals, consulting at Boston Consulting Group, and entrepreneurship. His early career took him to Russia, Ukraine, and Kazakhstan in the 1990s, where he engaged with diverse stakeholders, from primary care physicians to high-level officials. These experiences honed his ability to listen to experts while challenging conventional approaches—a skill he considers critical in the dynamic medtech sector.
“Medtech is much more open and diverse than biotech, with less defined regulatory pathways,” Paublant noted during the podcast. “This breadth of experience is valuable because you need to challenge experts to go faster and with less money.” His global perspective and adaptability have shaped Orixha’s mission to push the boundaries of medical technology, mirroring the USD Discovery District’s goal of fostering innovation through collaboration.
Orixha’s Mission: Revolutionizing Post-Cardiac Arrest Care
Orixha’s flagship technology, a liquid ventilator named Vent2Cool, represents a paradigm shift in treating post-cardiac arrest syndrome (PCAS). Developed over 20 years through academic collaborations with the University of Sherbrooke in Canada and the École Vétérinaire d’Alfort in France, the technology uses a biocompatible, oxygen-rich liquid to ventilate patients, rapidly cooling the body to protect vital organs. “We push just under one liter of breathable liquid into the lungs every 10 seconds, cooling the patient to 32–33°C within 15–20 minutes,” Paublant explained. This rapid induction of therapeutic hypothermia dampens the cytokine cascade that exacerbates organ damage post-cardiac arrest.
The technology’s potential extends beyond PCAS to conditions like acute respiratory distress syndrome (ARDS), where the anti-inflammatory properties of breathable liquids could restore lung function. As Orixha enters clinical trials, Mr. Paublant envisions the technology becoming a global standard in intensive care units by 2030–2031, delivering both clinical and economic value.
Leadership Philosophy: Decisiveness and Collective Intelligence
Paublant’s leadership philosophy emphasizes decisive action and collective intelligence, critical for navigating the complexities of medtech startups. “It’s always better to make a decision, even if it’s the wrong one, than to procrastinate,” he asserted. He advocates for a transparent decision-making process, ensuring team members understand whether decisions are collective or individual. This approach fosters a culture of accountability and adaptability, essential for startups operating at the frontier of science.
Mentorship has also played a pivotal role in Paublant’s career. He credits mentors who helped align Orixha’s founding team, and his own training in business coaching during the COVID years. “Mentorship is a two-way street,” Paublant noted. “You learn as much from mentoring others as you do from being mentored.”
Financial Discipline: Cash is King
For medtech entrepreneurs, Paublant’s advice is clear: “Cash is king.” He warns against the pitfalls of overspending after successful fundraising, citing the risk of rapid cash burn on non-essential hires or consultants. “You might raise $20 million and think you’re set, but 18 months later, you’re wondering where it went,” he cautioned. Instead, he recommends prioritizing investments in critical milestones and building a lean, high-quality team.
Looking Ahead: A Legacy of Impact
Paublant sees Orixha as his final entrepreneurial venture, with a goal to retire in seven years after establishing liquid ventilation as a clinical standard. Beyond PCAS, Orixha is exploring applications for ARDS and other conditions, leveraging the technology’s anti-inflammatory and oxygen-delivery capabilities. “We’re transforming 20 years of research into real clinical value for patients and financial value for shareholders,” Paublant said.
Fabrice Paublant’s journey from global pharmaceutical markets to leading Orixha’s liquid ventilation revolution exemplifies the power of diverse experiences, decisive leadership, and collaborative innovation. As the USD Discovery District continues to build a vibrant biotech ecosystem in Sioux Falls, stories like Paublant’s highlight the potential for transformative technologies to drive economic and societal impact.
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